Original Investigation

Bilevel Positive Airway Pressure and Continuous Albuterol for Pediatric Asthma Exacerbations

JAMA Network Open 10.1001/jamanetworkopen.2026.30627

August 26, 2026 at 11:00 AM EDT

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In this randomized clinical trial of early initiation of BPAP in the ED, no clinically significant decrease in the duration of continuous β-agonist therapy in pediatric patients presenting with moderate asthma exacerbations was observed. Additional open-label studies in a more severe asthma cohort are required to better inform clinical practice.

Corresponding Author: Patrick T, Wilson, MD, MPH, Department of Pediatrics, University of Colorado Anschutz School of Medicine, 13121 E 17th Ave, MS8414, Aurora, CO 80045 (patrick.t.wilson@cunaschutz.edu).

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