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Safety and Mental Health Outcomes of Oregon State-Regulated Psilocybin Services

JAMA Network Open 10.1001/jamanetworkopen.2026.30608

August 19, 2026 at 11:00 AM EDT

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In this multisite cohort of participants receiving state-regulated psilocybin services in Oregon, serious adverse reactions were uncommon. Most participants reported improvements in mental health, wellness, and life satisfaction. Longitudinal findings support safety and potential benefits that can inform clinicians, policymakers, and the public as other state-regulated psychedelic services emerge.

Meeting Information

This paper is being presented at the Oregon Psychedelic Innovation Summit.

Corresponding Author: P. Todd Korthuis, MD, MPH, Oregon Health Korthuis@ohsu.edu).

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