Original Investigation

Long-Term Fatigue After Treatment for Breast Cancer

JAMA Network Open 10.1001/jamanetworkopen.2026.29862

August 18, 2026 at 11:00 AM EDT

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In this cohort study of patients with BC, clinically relevant fatigue increased in 34% of patients 2 years after initiating cancer treatment mediated partly by depressive symptoms and perceived stress regardless of cardiovascular risk factors, age, or change in left ventricular ejection fraction and/or strain.

Corresponding Author: W. Gregory Hundley, MD, Pauley Heart Center, Division of Cardiology, Internal Medicine, Virginia Commonwealth University, 1200 E Broad St, PO Box 980335, Richmond, VA 23298 (greg.hundley@vcuhealth.org).

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