Fecal Occult Blood Screening Outcomes Adjusted for Contamination Bias and Nonadherence

In this cohort study of population-based FOBT screening, screening invitation was associated with a 26% reduction in CRC mortality and participation was associated with a 43% reduction, after accounting for contamination and nonadherence. These findings suggest that bias adjustment is important when evaluating screening programs, and these findings support efforts to increase screening uptake.

Corresponding Author: Johannes Blom, MD, PhD, Department of Clinical Science and Education, Karolinska Institutet, Södersjukhuset, Sjukhusbacken 10, 118 83 Stockholm, Sweden (johannes.blom@ki.se).

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