Low-Dose Hydrocortisone and Cognition in Women With HIV

In this randomized clinical trial, LDH produced acute and short-term improvements in verbal learning, memory, and attention in virally suppressed women with HIV. These findings suggest that HPA axis modulation may represent a therapeutic pathway for cognitive dysfunction in HIV. Peripheral biomarkers did not account for these cognitive benefits, suggesting that other biological mechanisms may underlie LDH’s effects.

Corresponding Author: Leah H. Rubin, PhD, MPH, Department of Neurology, Johns Hopkins University, 600 N Wolfe St, Carnegie 303, Baltimore, MD 21287-7613 (lrubin@jhu.edu).

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