Original Investigation

Transcranial Electrical Stimulation and Delirium Among Postoperative Patients

JAMA Network Open 10.1001/jamanetworkopen.2026.28284

August 18, 2026 at 11:00 AM EDT

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In this randomized clinical trial of tES for POD, there was no evidence for a uniform effect of postoperative tES on the incidence of POD, but it suggested a benefit of parietal α oscillatory enhancement for patients with longer surgery. Future research has to test the specific effect on vulnerable groups, examine the optimal timing for tES application to modulate POD, and investigate the value of personalizing tES parameters.

Corresponding Author: Daria Antonenko, PhD, Department of Neurology, University Medicine Greifswald, Ferdinand-Sauerbruch-Straße 1, D-17475 Greifswald, Germany (daria.antonenko@med.uni-greifswald.de).

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