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Editor's Pick Original Investigation

A Hybrid Lifestyle Program and Metabolic Health in Adults With Obesity

JAMA Network Open 10.1001/jamanetworkopen.2026.26884

August 11, 2026 at 11:00 AM EDT

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In this randomized clinical trial of 200 adults with obesity receiving care in Brazil’s public health care system, a hybrid-format lifestyle intervention did not improve the likelihood of achieving 5% or greater weight loss in the intention-to-treat analysis. However, secondary and per-protocol analyses suggested potential cardiometabolic benefits among adherent participants, warranting further investigation.

This Original Investigation has an accompanying commentary.

Corresponding Author: Graziele Souza de Menezes Amorim Coelho, MS, Rua Dr. Enéas de Carvalho Aguiar, 155 - 5° andar, Bloco 4B - Sala 11A, São Paulo, SP, 05403-000, Brasil (graziele.amc@gmail.com).

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