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Original Investigation

Global and Domain-Specific Cognitive Outcomes After Catheter Ablation for Atrial Fibrillation

JAMA Network Open 10.1001/jamanetworkopen.2026.26642

July 31, 2026 at 11:00 AM EDT

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In this prospective observational cohort study of 75 patients undergoing CA for AF, ablation was not associated with cognitive decline and was instead associated with modest short-term improvements in selected cognitive domains. Domain-specific assessment detected changes not captured by global cognitive screening, suggesting that modern ablation techniques may be associated with early subtle cognitive gains.

Corresponding Author: Sotirios Chiotis, MD, Third Department of Cardiology, Hippokration General Hospital, Aristotle University of Thessaloniki, Konstantinoupoleos 49, 54642, Greece (sotirischg@gmail.com).

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