Plasma Amyloid-β 1-40 and Postoperative Delirium After Cardiac Surgery

Are plasma Alzheimer disease biomarkers associated with postoperative delirium (POD) risk in older adults undergoing elective cardiac surgery? In this cohort study of 491 patients, elevated plasma amyloid-β 1-40 (Aβ1-40) levels were significantly associated with higher POD risk, independent of age and baseline cognition. Multivariable models combining Aβ1-40 with clinical factors and Montreal Cognitive Assessment showed improved risk estimation of POD compared with clinical variables alone. These findings suggest that preoperative plasma Aβ1-40 may serve as a modest but independent risk factor for POD in older patients undergoing cardiac surgery, offering potential value for future multimodal risk stratification.

Corresponding Author: Christine A. F. von Arnim, MD, Department of Geriatrics, University Medical Center Göttingen (UMG), Georg-August-University, Robert-Koch-Str. 40, 37075 Göttingen, Germany (christine.arnim@med.uni-goettingen.de).

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