Original Investigation

Street-Based Hepatitis C Treatment and Patient Experiences Among Adults Experiencing Unsheltered Homelessness

JAMA Network Open 10.1001/jamanetworkopen.2026.23334

July 16, 2026 at 11:00 AM EDT

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What are the perspectives of patients experiencing unsheltered homelessness who are engaged in street-based hepatitis C virus (HCV) treatment?In this qualitative study with 15 participants, adults experiencing unsheltered homelessness described common facilitators and barriers to HCV care, identified far-reaching psychosocial benefits of engaging with treatment beyond just achieving cure, and called for increased outreach and education about HCV treatment.These findings suggest that street-based models of care are a promising approach to increasing access to HCV treatment for patients experiencing unsheltered homelessness; policy changes facilitating widespread access to HCV treatment are needed.

Corresponding Author: Alexis Coulourides Kogan, PhD, MSG, Department of Family Medicine and Geriatrics, Keck School of Medicine of USC, 1845 N Soto St, SSB 1, Ste 203, Los Angeles, CA 90032 (acoulour@usc.edu).

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