Gestational Exposure to 10 Classes of Priority Chemicals and Birth Outcomes in the ECHO Cohort

Are gestational exposures to 10 classes of widely used chemicals associated with younger gestational age at birth or lower birth weight?In this cohort study measuring 113 analytes in 5318 maternal gestational urine samples, multiple phthalates or alternative plasticizers and polycyclic aromatic hydrocarbons were associated with younger gestational age at birth or lower birth weight scores.This study indicates that reducing gestational exposure to chemicals, particularly phthalates or alternative plasticizers and polycyclic aromatic hydrocarbons, could improve birth outcomes and future child health.

Corresponding Authors: Jessie P. Buckley, PhD, MPH, Department of Epidemiology, Gillings School of Global Public Health, University of North Carolina at Chapel Hill, 135 Dauer Dr, Chapel Hill, NC 27599 (Jessie.Buckley@unc.edu); Tracey J. Woodruff, PhD, MPH, Department of Epidemiology and Population Health, School of Medicine, Stanford University, 300 Pasteur Dr, Stanford, CA (traceyw@stanford.edu).

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