Frontal Release Signs and Future Decline in Research Participants With Intact Cognition

Are frontal release signs (FRS), such as snout, grasp, and palmomental reflexes, associated with future cognitive decline?In this cohort study that included 873 older participants with intact cognition or mild impairment, having 2 or more FRS (FRS positive) was associated with increased hazard of dementia for those who were cognitively intact at baseline, with more participants who were FRS positive progressing to dementia during follow-up compared with participants who were not FRS positive.These findings suggest that FRS should serve as an adjunct to other cognitive screening measures in the clinic.

Corresponding Author: Lauren G. Bojarski, DO, MS, University of Kentucky Sanders-Brown Center on Aging, 46 Tuscan Dr, Morgantown, WV 26508 (lauren.bojarski@gmail.com).

Link to the article in your story

We encourage you to link out to this article in your story using the link below. It includes an access token that will give free access to the article for your readers up to one year after publication. (The link will be live after the article publishes and embargo is lifted.)

Please see the article for additional information, including full author list, author contributions and affiliations, conflict of interest and financial disclosures, and funding and support.

Need more information? Contact us.