Original Investigation

Early Neurodevelopmental Outcomes in Children With Congenital Heart Disease

JAMA Network Open 10.1001/jamanetworkopen.2026.15885

June 01, 2026 at 11:00 AM EDT

Read the full article

Which clinical variables are associated with early neurodevelopmental outcomes in pediatric patients with congenital heart disease?This cross-sectional study of 868 children found clinical variables associated with neurodevelopmental outcomes included the presence of a genetic diagnosis, cardiac diagnosis, birth weight, sex, age at repair, length of stay, number of catheterizations, primary caregiver education, and Child Opportunity Index.This study’s results suggest that while the presence of a genetic diagnosis is associated with outcomes, early repair may be a variable of interest for future studies investigating neuroprotective strategies in congenital heart disease.

Corresponding Author: Mike Seed, MBBS, Division of Cardiology, Department of Paediatrics, Hospital for Sick Children, University of Toronto, 555 University Ave, Toronto, Ontario, M5G 1X8, Canada (mike.seed@sickkids.ca).

Link to the article in your story

We encourage you to link out to this article in your story using the link below. It includes an access token that will give free access to the article for your readers up to one year after publication. (The link will be live after the article publishes and embargo is lifted.)

Please see the article for additional information, including full author list, author contributions and affiliations, conflict of interest and financial disclosures, and funding and support.

Need more information? Contact us.

Editor's Picks