Once-Weekly Semaglutide in Adults With Daily Cigarette Use

Does semaglutide reduce cigarette use, craving, and body weight in people who smoke cigarettes but are not attempting cessation?In this randomized clinical trial including 24 participants, the effects of semaglutide on laboratory cigarette smoking and resistance to smoking were not significant in primary interaction tests, but change score analyses indicated that semaglutide significantly reduced laboratory smoking from before to after treatment. Semaglutide led to significant reductions in weekly cigarette craving, body weight, and hemoglobin A relative to placebo, without significantly reducing number of cigarettes smoked per day.These findings suggest that glucagon-like peptide-1 receptor agonist monotherapy may alter some nicotine outcomes in people who smoke, irrespective of cessation treatment.

Corresponding Author: Christian S. Hendershot, PhD, Keck School of Medicine, University of Southern California, 1845 N Soto St, Ste 201, Los Angeles, CA 90089 (christian.hendershot@usc.edu).

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