Pancreatic Cancer Risk in Patients With Low-Risk Cystic Lesions

Which baseline factors are associated with long-term pancreatic cancer incidence among patients with low-risk pancreatic cystic lesions (PCLs)?In this cohort study of 6064 patients with low-risk PCLs followed up for 20 145 person-years, pancreatic cancer incidence was 1.89 cases per 1000 person-years, approximately 14-fold higher than the general population rate. Approximately one-third of cancers arose outside the cyst site; 26.3% occurred more than 5 years after PCL detection.These findings suggest that low-risk PCLs carry a nonnegligible long-term risk of cancer, supporting the need for personalized surveillance strategies.

Corresponding Author: Arya Haj Mirzaian, MD, MPH, Harvard Medical School, Department of Radiology, Brigham and Women’s Hospital, 75 Francis St, Boston, MA 02115 (ahaj-mirzaian@bwh.harvard.edu).

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