Original Investigation

Medical Record Abstraction for Quality Improvement in Sepsis Care Using Artificial Intelligence

JAMA Network Open 10.1001/jamanetworkopen.2026.11885

June 25, 2026 at 11:00 AM EDT

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Can automated assessment of a complex care quality measure with more timely feedback improve measure performance?In this cluster randomized trial of 66 physicians treating 301 patients, the use of a large language model to automatically assess a complex measure for severe sepsis and septic shock and deliver targeted feedback improved quality metric performance. No change in 30-day mortality was observed among patients with sepsis cared for by physicians in the control and intervention groups.These findings suggest that artificial intelligence may enable quality clinical integration to address limitations in current quality measurement.

Corresponding Authors: Aaron Boussina, PhD, Division of Biomedical Informatics, University of California, San Diego, 9500 Gilman Dr, La Jolla, CA 92093 (aboussina@health.ucsd.edu), and Gabriel Wardi, MD, Department of Emergency Medicine, University of California, San Diego, 200 W Arbor Dr, San Diego, CA 92103 (gwardi@health.ucsd.edu).

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