Original Investigation

AI-Assisted Line-Field Confocal Optical Coherence Tomography to Detect Subclinical Basal Cell Carcinoma

JAMA Dermatology 10.1001/jamadermatol.2026.2992

August 19, 2026 at 11:00 AM EDT

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In this cross-sectional feasibility study, the findings suggest that systematic screening with AI-assisted LC-OCT may be a feasible approach for BCC detection at a preclinical stage in populations at high risk for BCC. Further prospective studies are needed to assess the sensitivity and cost-effectiveness of this method, and whether early detection translates to tangible clinical benefit before implementation in routine care can be recommended.

Corresponding Author: Moritz Ronicke, MD, Department of Dermatology, Uniklinikum Erlangen, Ulmenweg 18, 91054 Erlangen, Germany (Moritz.ronicke@uk-erlangen.de).

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