Progression From Acute to Chronic Urticaria

Are there clinical, laboratory, or treatment-related factors associated with progression from acute to chronic urticaria?In this systematic review of 16 studies (52 564 patients), no reliable baseline factors associated with progression were identified. Progression rates varied (5.8% to 36.0%) by study setting, and initial disease severity, clinical and laboratory markers, and use of systemic corticosteroids during the acute phase were not consistently associated with chronicity.These findings suggest current evidence does not support aggressive acute-phase treatment to prevent chronicity or routine use of biomarkers to identify patients at risk of chronicity; thus, clinical management should focus on symptom control and structured follow-up.

Corresponding Author: Enrique Gómez de la Fuente, MD, PhD, Department of Dermatology, Ramón y Cajal University Hospital, Carretera de Colmenar Viejo, Km 9.1. 28034 Madrid, Spain (enrique.gomezdelafuente@salud.madrid.org).

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