JAMA Dermatology Clinicopathological Challenge

Diffuse Pruritic Maculopapular Rash With Pitted NecrosisDiffuse Pruritic Maculopapular Rash With Pitted Necrosis—CaseDiffuse Pruritic Maculopapular Rash With Pitted Necrosis—Diagnosis

JAMA Dermatology 10.1001/jamadermatol.2026.0381

May 27, 2026 at 11:00 AM EDT

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A previously healthy woman in her 30s presented with a diffuse maculopapular rash, most prominently on her legs, with pitted necrotic spots, black eschar, and serous fluid weeping with diffuse edema. Histopathology showed areas with abnormal aggregates composed almost entirely of small T cells with no significant cytomorphologic atypia and numerous admixed eosinophils. What is your diagnosis?

Corresponding Author: Luke Y. C. Chen, MD, Division of Hematology, Dalhousie University, 1276 S Park St, Bethune Building, Ste 416, Halifax, NS B3H 2Y9, Canada (luke.chen@nshealth.ca).

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