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Causal Endotype–Based Classification of Myocardial Infarction

JAMA Cardiology 10.1001/jamacardio.2026.3794

August 29, 2026 at 10:15 AM EDT

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In this study, a causal endotype–based classification of MI identified distinct underlying mechanisms and clinical profiles that were not fully captured by the type 1/type 2 framework. This approach may complement the UDMI by improving characterization of MI heterogeneity.

Meeting Information: ESC 2026

This paper will be presented during European Society of Cardiology Congress in Munich, Germany.

Local Embargo Time: 16:15 (4:15 P.M.) CEST.

ESC Presentation: Tommaso Manaresi will present the findings during an ePoster round, “Myocardial infarction beyond the standard paradigm: endotypes, risk gaps, and real-world outcomes,” at Exchange Circle 5 in the Research Gateway.

Related Content: This paper has an accompanying editorial.

Corresponding Author: Carmine Pizzi, MD, Department of Medical and Surgical Sciences (DIMEC), Alma Mater Studiorum-University of Bologna, Bologna, Italy (carmine.pizzi@unibo.it).

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