Catheter-Based Left Atrial Appendage Closure vs Oral Anticoagulation in Patients With Atrial Fibrillation

In patients with AF, at long-term follow-up, transcatheter LAAC was associated with similar rates of any type of stroke and major bleeding compared with OAC, while increasing the risk of ischemic stroke and lowering the risk of nonprocedure-related major bleeding. These findings do not support the routine use of LAAC as a first-line strategy for stroke prevention in patients with AF at moderate to high risk of stroke.

Corresponding Author: Davide Capodanno, MD, PhD, Division of Cardiology, Azienda Ospedaliero-Universitaria Policlinico Rodolico – San Marco, Via Santa Sofia 78, 95123 Catania, Italy (davide.capodanno@unict.it).

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