Measured and Estimated Glomerular Filtration Rates and Risk of Adverse Health Outcomes

What is the association between measured glomerular filtration rate (mGFR) and adverse clinical outcomes?In this observational cohort study of 6174 adults in Sweden, compared with an mGFR of 90 mL/min/1.73 m, mGFR of 60 mL/min/1.73 m was associated with a statistically significant higher rate of all-cause mortality (27.6 vs 22.4 per 1000 person-years) and kidney failure with replacement therapy (1.2 vs 0.4 per 1000 person-years).Among adults in Sweden, compared with an mGFR of 90 mL/min/1.73 m, mGFR of 60 mL/min/1.73 m was associated with higher rates of mortality and kidney failure.

Corresponding Author: Edouard L. Fu, PhD, Department of Clinical Epidemiology, Leiden University Medical Center, Albinusdreef 2, 2333 ZA Leiden, the Netherlands (e.l.fu@lumc.nl).

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