The CRT-Estimands Framework for Cluster Randomized Trials

This Viewpoint discusses some specific challenges in defining estimands for cluster randomized trials and illustrates how the CRT-Estimands Framework can be applied to improve the interpretation of trial results.

Corresponding Author: Brennan C. Kahan, PhD, Medical Research Council Clinical Trials Unit, University College London, 90 High Holborn, London, England WC1V 6LJ (b.kahan@ucl.ac.uk).

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