High-Dose Intravenous Vitamin C and Mortality and Organ Dysfunction in Severe Burn Injury

Does high-dose intravenous vitamin C reduce a composite of 28-day mortality and persistent organ dysfunction in patients with severe burn injury?In this randomized clinical trial that included 238 patients with severe burns, the primary composite outcome of 28-day mortality and persistent organ dysfunction occurred in 40.8% of patients in the intravenous vitamin C group compared with 29.7% in the placebo group. At the first prespecified interim analysis, this result crossed the futility/harm threshold, prompting early termination of the trial.High-dose intravenous vitamin C did not reduce mortality and organ dysfunction and may be associated with harm in patients with severe burn injury.

Corresponding Author: Christian Stoppe, MD, Department of Anaesthesiology and Intensive Care, Emergency and Pain Medicine, University Hospital Würzburg, Oberdürrbacher-Straße 6, 97080 Würzburg, Germany (christian.stoppe@gmail.com).

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