JAMA Network Open

EMBARGOED FOR RELEASE: 11 A.M. ET, THURSDAY, MAY 8, 2025

Media advisory: The full study and commentary are linked to this news release.

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About JAMA Network Open: JAMA Network Open is an online-only open access general medical journal from the JAMA Network. On weekdays, the journal publishes peer-reviewed clinical research and commentary in more than 40 medical and health subject areas. Every article is free online from the day of publication. 

About The Study: In this cohort study of 12,480 mother-offspring pairs, researchers found that pre-pregnancy obesity, gestational diabetes, and hypertensive disorders of pregnancy, alone or in various combinations, were prospectively associated with higher offspring blood pressure at an early age and with an increased rate of blood pressure change from age 2 to 18 years, with the most profound associations with diastolic blood pressure among female offspring and with systolic blood pressure among Black offspring. These findings suggest that protecting pregnant individuals from cardiometabolic risk factors may promote healthier blood pressure in the next generation.

Corresponding Author: To contact the corresponding author, Shohreh F. Farzan, PhD, email sffarzan@usc.edu.

(doi:10.1001/jamanetworkopen.2025.9205)

Editor’s Note: Please see the article for additional information, including other authors, author contributions and affiliations, conflict of interest and financial disclosures, and funding and support.

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