Estimating Savings Opportunities From Therapeutic Substitutions of High-Cost Generic Medications

JAMA Network Open


Media advisory: The full study is linked to this news release.

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About The Study: In this analysis of the top 1,000 generics in Colorado’s all-payer claims database in 2019, researchers identified 45 high-cost products that had lower-cost therapeutic alternatives of same clinical value. Overall, high-cost generics were 15.6 times more expensive than their therapeutic alternatives (median values). If the lower-cost alternatives had been used, total spending would have been reduced by 88%. Substitution of high-cost generics may provide a simple pathway to offer the same therapeutic benefit at lower cost to patients and insurers.

Authors: Mariana P. Socal, M.D., Ph.D., of the Johns Hopkins Bloomberg School of Public Health in Baltimore, is the corresponding author.



Editor’s Note: Please see the article for additional information, including other authors, author contributions and affiliations, conflict of interest and financial disclosures, and funding and support.

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