Does Vitamin D Reduce Likelihood of Wheezing in Preterm Black Infants?



Media advisory: To contact corresponding author Anna Maria Hibbs, M.D., M.S.C.E., email Ansley Gogol ( or Katelyn McCarthy ( The full study is available on the For The Media website.

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Bottom Line: Black infants born preterm who received sustained vitamin D supplementation had a lower likelihood of recurrent wheezing by age 1.

Why The Research Is Interesting: Wheezing is a common complication of preterm birth and black infants have higher rates of prematurity-associated wheezing. This randomized clinical trial assessed two vitamin D supplementation strategies in preventing recurrent wheezing.

Who and When: 300 black infants born at 28 to 36 weeks between January 2013 and January 2016.

What (Study Interventions and Measures): 400 IU/day of vitamin D until 6 months of age adjusted for prematurity or a diet-limited approach (stopping supplementation once a baby was receiving at least 200 IU/day of vitamin D from formula or a fortifier added to human milk) (interventions); recurrent wheezing by age 1 (outcome).

How (Study Design): This was a randomized clinical trial (RCT). RCTs allow for the strongest inferences to be made about the true effect of an intervention. However, not all RCT results can be replicated in real-world settings because patient characteristics or other variables may differ from those studied in the RCT.

Authors: Anna Maria Hibbs, M.D., M.S.C.E., Case Western Reserve University School of Medicine, Cleveland, and coauthors


Study Limitations: There was the potential for misclassification of wheezing by the study’s questionnaire.

Study Conclusions:


Related material: The editorial, “Prenatal vs Infant Vitamin D Supplementation and the Risk of Wheezing in Childhood,” by Frank R. Greer, M.D., University of Wisconsin School of Medicine and Public Health, Madison, is also available on the For The Media website.

For more details and to read the full study, please visit the For The Media website.


Editor’s Note: Please see the article for additional information, including other authors, author contributions and affiliations, financial disclosures, funding and support, etc.

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For more information, contact JAMA Network Media Relations at 312-464-JAMA (5262) or email


Translation in Simplified Chinese




媒体咨询:联系通讯作者Anna Maria Hibbs, M.D., M.S.C.E.,请发电子邮件到Ansley Gogol ( 或Katelyn McCarthy (



概要: 根据《美国医学会杂志》(JAMA)发表的一项研究,接受持续维生素D补充治疗的早产黑人婴儿在1岁时患复发性喘鸣的可能性较低。






研究内容(研究干预及措施):每天补充400 IU 的维生素D,直到出生后6个月调整为早产或饮食限制(一旦婴儿能通过奶粉或添加到母乳中的强化剂来接受至少每天200 IU 的维生素D,则停止补充)(干预); 1岁时复发性喘鸣(结果)。


如何研究(研究设计):这是一项随机临床试验(RCT)。 RCT可以对干预的真实效果做出最强有力的推论。 但是,并非所有的RCT结果都可以在现实中被重复,因为患者特征或其他变量可能与RCT中所研究的不同。


作者:Anna Maria Hibbs, M.D., M.S.C.E., 凯斯西储大学医学院,克利夫兰,以及合作者


研究结果:在1岁时患复发性喘鸣:持续补充组中的31.1%的婴儿; 饮食限制组中的41.8%的婴儿。





结论及相关性  在早产的黑人婴儿中,与饮食限制性补充相比,持续补充维生素D会减少在12个月时患复发性喘鸣的风险。还需要进一步的研究来了解补充维生素D对早产婴儿喘鸣影响的内在机理及长期作用。


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