Does Vitamin D Reduce Likelihood of Wheezing in Preterm Black Infants?

JAMA

EMBARGOED FOR RELEASE: 11 A.M. (ET), TUESDAY, MAY 22, 2018

Media advisory: To contact corresponding author Anna Maria Hibbs, M.D., M.S.C.E., email Ansley Gogol (Ansley.Gogol@case.edu) or Katelyn McCarthy (Katelyn.McCarthy@UHhospitals.org). The full study is available on the For The Media website.

Want to embed a link to this report in your story? Link will be live at the embargo time http://jamanetwork.com/journals/jama/fullarticle/10.1001/jama.2018.5729

Translation available: A translation in simplified Chinese is available below.

本篇新闻发布稿件备有翻译版本:以下内容为中文简体翻译版本

 

Bottom Line: Black infants born preterm who received sustained vitamin D supplementation had a lower likelihood of recurrent wheezing by age 1.

Why The Research Is Interesting: Wheezing is a common complication of preterm birth and black infants have higher rates of prematurity-associated wheezing. This randomized clinical trial assessed two vitamin D supplementation strategies in preventing recurrent wheezing.

Who and When: 300 black infants born at 28 to 36 weeks between January 2013 and January 2016.

What (Study Interventions and Measures): 400 IU/day of vitamin D until 6 months of age adjusted for prematurity or a diet-limited approach (stopping supplementation once a baby was receiving at least 200 IU/day of vitamin D from formula or a fortifier added to human milk) (interventions); recurrent wheezing by age 1 (outcome).

How (Study Design): This was a randomized clinical trial (RCT). RCTs allow for the strongest inferences to be made about the true effect of an intervention. However, not all RCT results can be replicated in real-world settings because patient characteristics or other variables may differ from those studied in the RCT.

Authors: Anna Maria Hibbs, M.D., M.S.C.E., Case Western Reserve University School of Medicine, Cleveland, and coauthors

Results:

Study Limitations: There was the potential for misclassification of wheezing by the study’s questionnaire.

Study Conclusions:

 

Related material: The editorial, “Prenatal vs Infant Vitamin D Supplementation and the Risk of Wheezing in Childhood,” by Frank R. Greer, M.D., University of Wisconsin School of Medicine and Public Health, Madison, is also available on the For The Media website.

For more details and to read the full study, please visit the For The Media website.

(doi:10.1001/jama.2018.5729)

Editor’s Note: Please see the article for additional information, including other authors, author contributions and affiliations, financial disclosures, funding and support, etc.

#  #  #

For more information, contact JAMA Network Media Relations at 312-464-JAMA (5262) or email mediarelations@jamanetwork.org.

 

Translation in Simplified Chinese

中文简体翻译版本

禁止提前报道指令解除时间:2018522日,星期二,东部时间上午11

 

媒体咨询:联系通讯作者Anna Maria Hibbs, M.D., M.S.C.E.,请发电子邮件到Ansley Gogol (Ansley.Gogol@case.edu) 或Katelyn McCarthy (Katelyn.McCarthy@UHhospitals.org)

 

维生素D是否会减少早产黑人婴儿患喘鸣的可能性?

概要: 根据《美国医学会杂志》(JAMA)发表的一项研究,接受持续维生素D补充治疗的早产黑人婴儿在1岁时患复发性喘鸣的可能性较低。

 

为何对该问题感兴趣:喘鸣是早产的常见并发症之一,而黑人婴儿早产相关性喘鸣的发生率较高。这项随机临床试验评估了两种维生素D补充方案对预防复发性喘鸣的效果。

 

研究参与者及时间:2013年1月至2016年1月期间出生的28至36周的300名黑人婴儿。

 

研究内容(研究干预及措施):每天补充400 IU 的维生素D,直到出生后6个月调整为早产或饮食限制(一旦婴儿能通过奶粉或添加到母乳中的强化剂来接受至少每天200 IU 的维生素D,则停止补充)(干预); 1岁时复发性喘鸣(结果)。

 

如何研究(研究设计):这是一项随机临床试验(RCT)。 RCT可以对干预的真实效果做出最强有力的推论。 但是,并非所有的RCT结果都可以在现实中被重复,因为患者特征或其他变量可能与RCT中所研究的不同。

 

作者:Anna Maria Hibbs, M.D., M.S.C.E., 凯斯西储大学医学院,克利夫兰,以及合作者

 

研究结果:在1岁时患复发性喘鸣:持续补充组中的31.1%的婴儿; 饮食限制组中的41.8%的婴儿。

 

研究局限:研究问卷有可能导致喘鸣分类错误。

 

研究结论:

结论及相关性  在早产的黑人婴儿中,与饮食限制性补充相比,持续补充维生素D会减少在12个月时患复发性喘鸣的风险。还需要进一步的研究来了解补充维生素D对早产婴儿喘鸣影响的内在机理及长期作用。

 

欲了解更多详情并阅读完整的研究报告,请访问For The Media网站:http://media.jamanetwork.com/