Comparison of Type 2 Diabetes Treatments in Improving Survival



Media advisory: To contact corresponding author Sean L. Zheng, B.M., B.Ch., M.A., M.R.C.P., email The full study is available on the For The Media website.

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Bottom Line: In a comparison of different classes of drugs used to lower blood sugar levels for patients with type 2 diabetes, sodium-glucose cotransporter 2 (SGLT-2) inhibitors or glucagon-like peptide 1(GLP-1) agonists were associated with a lower risk of death than dipeptidyl peptidase 4 (DPP-4) inhibitors or control (placebo or no treatment).

Why The Research Is Interesting: Several drug classes have emerged that are effective in improving blood sugar control for patients with type 2 diabetes, including SGLT-2 and DPP-4 inhibitors and GLP-1 agonists. The clinical effectiveness of these drugs compared to each other is not known.

Who and When: 176,310 study participants with type 2 diabetes in 236 randomized clinical trials in databases through October 2017

What (Study Measures): SGLT-2 inhibitors, GLP-1 agonists, DPP-4 inhibitors, and control (placebo, no treatment) (interventions); death from any cause (outcome).

How (Study Design): This was a network meta-analysis, which combines the results of multiple studies identified in a systematic review and quantitatively summarizes the overall association between interventions and outcomes measured across all studies.

Authors: Sean L. Zheng, B.M., B.Ch., M.A., M.R.C.P., Imperial College Healthcare NHS Foundation Trust, London, and coauthors


Study Limitations: Network meta-analysis respects randomization of clinical trials, but itself represents observational data, preventing conclusions on causality from being inferred.

Study Conclusions: In patients with type 2 diabetes, the use of SGLT-2 inhibitors or GLP-1 agonists was associated with better survival than DPP-4 inhibitors.

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Translation in Simplified Chinese

禁止提前报道指令解除时间:2018417 星期二,美国东部时间上午11


媒体咨询:联系通讯作者Sean L. Zheng, B.M., B.Ch., M.A., M.R.C.P,请发电子邮件到




概要: 根据《美国医学会杂志》(JAMA)发表的一项研究,对能降低2型糖尿病患者的血糖水平的不同类别药物的比较显示,与二肽基肽酶4(DPP-4)抑制剂或对照组(安慰剂或不治疗)相比,钠 – 葡萄糖协同转运蛋白2(SGLT-2)抑制剂或胰高血糖素样肽1(GLP-1)激动剂会导致死亡风险的降低。


为何对该问题感兴趣:目前已经出现了几种能够有效改善2型糖尿病患者的血糖控制的药物类别,包括SGLT-2和DPP-4抑制剂以及GLP-1激动剂。 但尚不清楚这些药物的临床效果的相互比较。




研究什么(研究内容):SGLT-2抑制剂,GLP-1激动剂,DPP-4抑制剂和对照(安慰剂,不治疗)(干预); 任何原因造成的死亡(结果)。





  • 与DPP-4抑制剂或对照组(安慰剂或不治疗)相比,SGLT-2抑制剂或GLP-1激动剂会导致死亡风险的降低。
  • 与安慰剂或不治疗相比,DPP-4抑制剂不会导致死亡风险的降低。




研究结论:与DPP-4抑制剂相比, 2型糖尿病患者使用SGLT-2抑制剂或GLP-1激动剂会导致更高的生存率。


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