JAMA Neurology

EMBARGOED FOR RELEASE: 11 A.M. (ET), WEDNESDAY, MAY 7, 2025

Media advisory: The full study is linked to this news release.

Embed this link to provide your readers free access to the full-text article This link will be live at the embargo time https://jamanetwork.com/journals/jamaneurology/fullarticle/10.1001/jamaneurol.2025.1718?guestAccessKey=f0ce6d56-973c-4c47-922b-ba20bb733830&utm_source=for_the_media&utm_medium=referral&utm_campaign=ftm_links&utm_content=tfl&utm_term=050725

About The Study: There was no evidence supporting a diagnosis of neurological syndrome of unknown cause (NSUC) in this cohort. The data inclusive of independent examinations and neuropathology strongly supported the presence of several neurodegenerative and non-neurodegenerative conditions. Unfounded concerns that a potentially fatal mystery disease, possibly induced by an environmental toxin, is causing the patients’ neurological symptoms has been amplified in traditional and social media. Second, independent clinical evaluations are needed for any patient given a diagnosis of NSUC.

Corresponding Author: To contact the corresponding author, Anthony E. Lang, MD, email anthony.lang@uhn.ca.

(doi:10.1001/jamaneurol.2025.1718)

Editor’s Note: Please see the article for additional information, including other authors, author contributions and affiliations, conflict of interest and financial disclosures, and funding and support.

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