Archives of General Psychiatry Study Highlights


Archives of General Psychiatry Study Highlights

  • Exposure to traffic-related air pollution, particulate matter and nitrogen dioxide during pregnancy and during the first year of a child’s life appears to be associated with an increased risk of autism (Online First, see news release below).
  • A multicenter study using magnetic resonance imaging of the brain that included 84 men (mean age 26 years) diagnosed with autism spectrum disorder (ASD) and 84 control participants (mean age 28 years) suggests that individuals with ASD have significant differences in cortical volume, which may be connected to its two components, cortical thickness and surface area. Overall, individuals with ASD had increased cortical thickness within frontal lobe regions and reduced surface area in other brain regions (Online First).
  • An imaging study of 20 men with autism spectrum disorder (ASD) (age range 18 to 31 years) and 20 healthy men suggests there was excessive microglial (brain cells that sense pathologic tissue alterations) activation in young men with ASD (Online First).   

(Arch Gen Psychiatry. Published online November 26, 2012. doi:10.1001/jamapsychiatry.2013.266; doi:10.1001/jamapsychiatry.2013.265; doi:10.1001/jamapsychiatry.2013.272. Available pre-embargo to the media at

Editor’s Note: Please see the articles for additional information, including other authors, author contributions and affiliations, financial disclosures, funding and support, etc. 


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