New, Persistent Opioid Use Common after Surgery

EMBARGOED FOR RELEASE: 11 A.M. (ET), WEDNESDAY, APRIL 12, 2017

Media Advisory: To contact Chad M. Brummett, M.D., email Kara Gavin at kegavin@med.umich.edu.

To place an electronic embedded link to this study in your story: This link will be live at the embargo time: http://jamanetwork.com/journals/jamasurgery/fullarticle/10.1001/jamasurg.2017.0504

JAMA Surgery

Among about 36,000 patients, approximately 6 percent continued to use opioids more than three months after their surgery, with rates not differing between major and minor surgical procedures, according to a study published by JAMA Surgery.

Millions of Americans undergo surgery each year, and many patients receive their first exposure to opioids following surgery. Despite increased focus on reducing opioid prescribing for long-term pain, little is known regarding the incidence and risk factors for persistent opioid use after surgery. Chad M. Brummett, M.D., of the University of Michigan Medical School, Ann Arbor, and colleagues used nationwide insurance claims data set from 2013 to 2014 to identify U.S. adults (ages 18 to 64 years) without opioid use in the year prior to surgery. For patients filling a perioperative opioid prescription, the researchers calculated the incidence of persistent opioid use for more than 90 days among patients who had not used opioids previously, after both minor and major surgical procedures, and assessed data for patient-level predictors of persistent opioid use.

A total of 36,177 patients met the inclusion criteria, with 29,068 (80 percent) receiving minor surgical procedures and 7,109 (20 percent) receiving major procedures. The group had an average age of 45 years and was predominately female (66 percent) and white (72 percent). The rates of new persistent opioid use were similar between the two groups, ranging from 5.9 percent to 6.5 percent. By comparison, the incidence in the nonoperative control group was only 0.4 percent. Risk factors independently associated with new persistent opioid use included preoperative tobacco use, alcohol and substance abuse disorders, mood disorders, anxiety, and preoperative pain disorders.

“New persistent opioid use after surgery is common and is not significantly different between minor and major surgical procedures but rather associated with behavioral and pain disorders. This suggests its use is not due to surgical pain but addressable patient-level predictors. New persistent opioid use represents a common but previously underappreciated surgical complication that warrants increased awareness,” the authors write.

(JAMA Surgery. Published online April 12, 2017.doi:10.1001/jamasurg.2017.0504. This study is available pre-embargo at the For The Media website.)

Editor’s Note: Please see the article for additional information, including other authors, author contributions and affiliations, financial disclosures, funding and support, etc.

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