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INCREASINGLY COMMON I-V-F PROCEDURE DOESN’T IMPROVE PREGNANCY OUTCOMES

INTRO: Couples dealing with infertility often use in vitro fertilization or I-V-F to help them get pregnant. In conventional I-V-F, fertilization of an egg occurs naturally but outside the body. Another type of I-V-F procedure is used when the egg can’t be fertilized that way, usually because of male infertility problems. A new study examined when, why and how often this alternative procedure was used compared with conventional I-V-F. Catherine Dolf explains in this week’s JAMA Report.

VIDEO
B-ROLL
Pictures of Luca and the family in hospital after he was born

AUDIO
VO
BABY LUKA ARRIVED SAFELY IN THIS WORLD AFTER REGINA AZUCKI (Ah-ZUT-ski) AND HER HUSBAND UNDERWENT SEVERAL ROUNDS OF IN VITRO FERTILIZATION OR I-V-F.

AUDIO
SOT/FULL Super@:07 Regina Azucki – IVF Patient Runs:08
“We tried for gosh, probably a year and then my son is two and a half now, so it’s just been amazing.”

VIDEO
B-ROLL
Graphic with sperm on side and words INTRACYTOPLASMIC SPERM INJECTION

AUDIO
VO
ONE TYPE OF I-V-F INCREASINGLY BEING USED IS CALLED INTRA-CYTO-PLASMIC SPERM INJECTION OR ICSI (Ick-See).

AUDIO
SOT/FULL Super@:21 Sheree L. Boulet, Dr.P.H., M.P.H – Centers for Disease Control and Prevention Runs:12
Sheree L. Boulet, Dr.P.H., M.P.H – Centers for Disease Control and Prevention
“ICSI is a type of in vitro fertilization where a single sperm is injected into an egg. Whereas for conventional IVF the sperm is penetrating the egg on its own.”
(Video covering 2nd half of bite: ICSI procedure under microscope)

VIDEO
B-ROLL
ICSI procedure under the microscope

AUDIO
VO
ICK-SEE IS MOSTLY RECOMMENDED WHEN THERE ARE PROBLEMS WITH THE MAN’S SPERM OR WHAT’S CALLED MALE FACTOR INFERTILITY.

AUDIO

VIDEO
B-ROLL
Dr. Mehta and Dr. Boulet walking down hallway, looking through microscope, ICSI procedure, doctors sitting at table, sperm under microscope

AUDIO
VO
DR. AKANKSHA (Ah-KANK-shah) MEHTA (Meh-Tah) FROM EMORY UNIVERSITY SCHOOL OF MEDICINE AND DR. SHEREE (SHERRY) BOULET (Boo-Lay) FROM THE CENTERS FOR DISEASE CONTROL AND PREVENTION AND CO-AUTHORS EXAMINED ICK-SEE PROCEDURES THAT USED ONLY FRESH EMBRYOS, NOT FROZEN, FROM 1996 THRU 2012. THEY COMPARED ICK-SEE OUTCOMES FROM THE FIVE MOST RECENT YEARS TO CONVENTIONAL I-V-F PROCEDURES. THEY ALSO LOOKED AT WHETHER OR NOT MALE INFERTILITY WAS PRESENT IN THESE CASES.

AUDIO
SOT/FULL Super@1:05 Akanksha Mehta, M.D., – Emory University School of Medicine Runs:14
“The use of ICSI has doubled since it was first introduced and the increase has been largely among cases where male factor infertility is absent.”

GXF FULL
JAMA COVER

AUDIO
VO
THE STUDY APPEARS IN JAMA, JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION.

AUDIO
SOT/FULL Super@1:23 Sheree L. Boulet, Dr.P.H., M.P.H – Centers for Disease Control and Prevention Runs:18
“Those cycles saw a four-fold increase in the use of ICSI over the study period. The use of ICSI did not improve reproductive outcomes such as pregnancy and live birth rates when compared with conventional IVF, regardless of whether or not there was a diagnosis of male factor infertility.”

(Video covering middle of bite: Dr. Boulet and Dr. Mehta in lab looking at microscope, pan to Dr. Boulet)

AUDIO
SOT/FULL Super@1:41 Akanksha Mehta, M.D., – Emory University School of Medicine Runs:13
“The benefit of this technology still remains very much only in cases where severe male factor infertility is present that would prevent natural fertilization from taking place.”

AUDIO
SOT/FULL Super@1:41 Akanksha Mehta, M.D., – Emory University School of Medicine Runs:13
“The benefit of this technology still remains very much only in cases where severe male factor infertility is present that would prevent natural fertilization from taking place.”

VIDEO
B-ROLL
Various pictures of Luka with his family

AUDIO
VO
DESPITE THE CHALLENGES, LUKA’S PARENTS ALWAYS STAYED POSITIVE DURING THE LONG WAIT FOR HIS ARRIVAL.

AUDIO
SOT/FULL Super@1:59 Regina Azucki – IVF Patient Runs:05
“He just makes me so happy and he’s just brought so much to our lives and so much joy.”

(Video covering 2nd part of bite: Pic of the entire family)

VIDEO
B-ROLL
Pic of baby Luka

AUDIO
VO
CATHERINE DOLF, THE JAMA REPORT.

TAG: ICSI (ICK-See) IS MORE EXPENSIVE THAN CONVENTIONAL I-V-F AND PREGNANCIES RESULTING FROM ICK-SEE HAVE BEEN ASSOCIATED WITH INCREASED RISK OF BIRTH DEFECTS, CHROMOSOMAL ABNORMALITIES AND AUTISM.

INTRO: Couples dealing with infertility often use in vitro fertilization or I-V-F to help them get pregnant. In conventional I-V-F, fertilization of an egg occurs naturally but outside the body. Another type of I-V-F procedure is used when the egg can’t be fertilized that way, usually because of male infertility problems. A new study examined when, why and how often this alternative procedure was used compared with conventional I-V-F. Catherine Dolf explains in this week’s JAMA Report.

VIDEO
B-ROLL
Pictures of Luca and the family in hospital after he was born

AUDIO
VO
BABY LUKA ARRIVED SAFELY IN THIS WORLD AFTER REGINA AZUCKI (Ah-ZUT-ski) AND HER HUSBAND UNDERWENT SEVERAL ROUNDS OF IN VITRO FERTILIZATION OR I-V-F.

AUDIO
SOT/FULL Super@:07 Regina Azucki – IVF Patient Runs:08
“We tried for gosh, probably a year and then my son is two and a half now, so it’s just been amazing.”

VIDEO
B-ROLL
Graphic with sperm on side and words INTRACYTOPLASMIC SPERM INJECTION

AUDIO
VO
ONE TYPE OF I-V-F INCREASINGLY BEING USED IS CALLED INTRA-CYTO-PLASMIC SPERM INJECTION OR ICSI (Ick-See).

AUDIO
SOT/FULL Super@:21 Sheree L. Boulet, Dr.P.H., M.P.H – Centers for Disease Control and Prevention Runs:12
Sheree L. Boulet, Dr.P.H., M.P.H – Centers for Disease Control and Prevention
“ICSI is a type of in vitro fertilization where a single sperm is injected into an egg. Whereas for conventional IVF the sperm is penetrating the egg on its own.”
(Video covering 2nd half of bite: ICSI procedure under microscope)

VIDEO
B-ROLL
ICSI procedure under the microscope

AUDIO
VO
ICK-SEE IS MOSTLY RECOMMENDED WHEN THERE ARE PROBLEMS WITH THE MAN’S SPERM OR WHAT’S CALLED MALE FACTOR INFERTILITY.

AUDIO

VIDEO
B-ROLL
Dr. Mehta and Dr. Boulet walking down hallway, looking through microscope, ICSI procedure, doctors sitting at table, sperm under microscope

AUDIO
VO
DR. AKANKSHA (Ah-KANK-shah) MEHTA (Meh-Tah) FROM EMORY UNIVERSITY SCHOOL OF MEDICINE AND DR. SHEREE (SHERRY) BOULET (Boo-Lay) FROM THE CENTERS FOR DISEASE CONTROL AND PREVENTION AND CO-AUTHORS EXAMINED ICK-SEE PROCEDURES THAT USED ONLY FRESH EMBRYOS, NOT FROZEN, FROM 1996 THRU 2012. THEY COMPARED ICK-SEE OUTCOMES FROM THE FIVE MOST RECENT YEARS TO CONVENTIONAL I-V-F PROCEDURES. THEY ALSO LOOKED AT WHETHER OR NOT MALE INFERTILITY WAS PRESENT IN THESE CASES.

AUDIO
SOT/FULL Super@1:05 Akanksha Mehta, M.D., – Emory University School of Medicine Runs:14
“The use of ICSI has doubled since it was first introduced and the increase has been largely among cases where male factor infertility is absent.”

GXF FULL
JAMA COVER

AUDIO
VO
THE STUDY APPEARS IN JAMA, JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION.

AUDIO
SOT/FULL Super@1:23 Sheree L. Boulet, Dr.P.H., M.P.H – Centers for Disease Control and Prevention Runs:18
“Those cycles saw a four-fold increase in the use of ICSI over the study period. The use of ICSI did not improve reproductive outcomes such as pregnancy and live birth rates when compared with conventional IVF, regardless of whether or not there was a diagnosis of male factor infertility.”

(Video covering middle of bite: Dr. Boulet and Dr. Mehta in lab looking at microscope, pan to Dr. Boulet)

AUDIO
SOT/FULL Super@1:41 Akanksha Mehta, M.D., – Emory University School of Medicine Runs:13
“The benefit of this technology still remains very much only in cases where severe male factor infertility is present that would prevent natural fertilization from taking place.”

AUDIO
SOT/FULL Super@1:41 Akanksha Mehta, M.D., – Emory University School of Medicine Runs:13
“The benefit of this technology still remains very much only in cases where severe male factor infertility is present that would prevent natural fertilization from taking place.”

VIDEO
B-ROLL
Various pictures of Luka with his family

AUDIO
VO
DESPITE THE CHALLENGES, LUKA’S PARENTS ALWAYS STAYED POSITIVE DURING THE LONG WAIT FOR HIS ARRIVAL.

AUDIO
SOT/FULL Super@1:59 Regina Azucki – IVF Patient Runs:05
“He just makes me so happy and he’s just brought so much to our lives and so much joy.”

(Video covering 2nd part of bite: Pic of the entire family)

VIDEO
B-ROLL
Pic of baby Luka

AUDIO
VO
CATHERINE DOLF, THE JAMA REPORT.

TAG: ICSI (ICK-See) IS MORE EXPENSIVE THAN CONVENTIONAL I-V-F AND PREGNANCIES RESULTING FROM ICK-SEE HAVE BEEN ASSOCIATED WITH INCREASED RISK OF BIRTH DEFECTS, CHROMOSOMAL ABNORMALITIES AND AUTISM.

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