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TWO THERAPIES TO TREAT SICKLE CELL DISEASE ARE UNDERUTILIZED

INTRO: Sickle cell disease is a life-threatening genetic disorder affecting almost a hundred thousand Americans. The disease is associated with severe pain and several chronic complications. During the last five years, an expert panel reviewed existing medical studies and trials on sickle cell disease. The report highlights two therapies that are effective but underutilized when it comes to treatment. More from Catherine Dolf in this week’s JAMA Report.

VIDEO
B-ROLL
Isaiah laying in chair, pic of Isaiah in Taekwando outfit

AUDIO
VO
ISAIAH BELL IS 12. HE LOVES FOOTBALL AND TAEKWANDO.

AUDIO
SOT/FULL Super@:04 Isaiah Bell – Sickle Cell Patient Runs:04
“I get to kick people in taekwondo…that’s just awesome.”

VIDEO
B-ROLL
Pic of Isaac with diploma, with friends

AUDIO
VO
ISAAC OKAH IS 18. HE’S HEADED TO COLLEGE AND WANTS TO BE AN ACTOR.

AUDIO
SOT/FULL Super@:13 Isaac Okah, Jr. – Sickle Cell Patient Runs:04
“There are so many things about acting that just intrigues me.”

VIDEO
B-ROLL
Split screen of Isaiah sitting with mom and Isacc walking with his mom

AUDIO
VO
JUST TWO OF THE THOUSANDS LIVING WITH SICKLE CELL DISEASE IN THE UNITED STATES.

AUDIO
SOT/FULL Super@ :20 George R. Buchanan, M.D., – UT Southwestern Medical Center Runs:08
“Pain is the major manifestation of people with sickle cell disease. The pain is unpredictable, it’s recurrent and it can be extremely severe.”

VIDEO
B-ROLL
Graphic: Sickle Cells, pain points in the body

AUDIO
VO
THE PAIN IS CAUSED BY SICKLE SHAPED RED BLOODS CELLS THAT BLOCK THE SMALL BLOOD VESSELS IN THE BODY. THIS CAUSES AN ARRAY OF SERIOUS HEALTH PROBLEMS.

AUDIO
SOT/FULL Super@ :35 George R. Buchanan, M.D., – UT Southwestern Medical Center Runs:14
“Many doctors are unfamiliar with how to treat these events. Having those physicians knowledgeable about sickle cell disease and familiar with the guidelines that are being recommended here will allow them to give better care to these patients.”

(Video covering middle of bite: Dr. Buchanan talking with Isaiah and his mom)

VIDEO
B-ROLL
Dr. Buchanan walking, sitting at microscope, GXF FULL JAMA COVER

AUDIO
VO
DR. GEORGE BUCHANAN FROM THE UNIVERSITY OF TEXAS SOUTHWESTERN MEDICAL CENTER AND A PANEL OF EXPERTS SPENT 5 YEARS REVIEWING MORE THAN 30 YEARS OF MEDICAL STUDIES AND TRIALS ON SICKLE CELL DISEASE. THIS SPECIAL COMMUNICATION APPEARS IN JAMA, JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION.

AUDIO
SOT/FULL Super@ 1:04 George R. Buchanan, M.D., – UT Southwestern Medical Center Runs:13
“There are improved treatments. Hydroxyurea is greatly effective in reducing pain and other complications and prolonging patients’ lives. Unfortunately most people aren’t taking that medicine yet and it’s a big problem.”

(Video covering 2nd half of bite: cu of Dr. Buchanan’s looking in microscope

VIDEO
B-ROLL
Isaac and mom talking, blood being tested, pic of Isaac’s eyes swollen shut

AUDIO
VO
ISAAC IS TAKING THIS F-D-A APPROVED MEDICATION WHICH DECREASES THE RIGIDITY AND INFLEXIBILITY OF HIS RED BLOOD CELLS. IT IS ALSO PREVENTING EPISODES LIKE THIS.

AUDIO
SOT/FULL Super@ 1:25 Voice of: Isaac Okah, Jr. – Sickle Cell PatientRuns:03
“My eyes got swollen shut. I couldn’t see at all.”

(Video covering bite: pic of eyes swollen shut)

AUDIO
SOT/FULL Super@ 1:34 Gift Okah – Isaac’s Mother Runs:08
“For almost 5 years now we have not had any pain crisis because he stayed on that medication.”

(Video covering 1st part of bite: Isaac and mom walking)

AUDIO
SOT/FULL Super@1:41 George R. Buchanan, M.D., – UT Southwestern Medical Center Runs:10
“Blood transfusions are an extremely important treatment for people with sickle cell disease either given acutely as a single time or on a monthly basis, long-term.”

(Video covering 1st part of bite: blood transfusion bag)

AUDIO
SOT/FULL Super@1:46 Natasha Jones – Isaiah’s Mother Runs:06
“The blood transfusions just kind of helped him stay on top of his game.”

AUDIO
SOT/FULL Super@ 1:52 Isaiah Bell – Sickle Cell Patient Runs:03
“It’s not too big of a problem for me.”

VIDEO
B-ROLL
Mircroscope behind graphics:
Panel Recommendations
Treating Severe Pain with Intravenous Opiods
Using Penicillin To Treat Children Up to Age Five
Isiah and Dr. Buchanan, Isaac talking with mom

AUDIO
VO
OTHER RECOMMENDATIONS INCLUDE, TREATING SEVERE PAIN WITH INTRAVENOUS OPIODS AND USING DAILY PENICILLIN TO PREVENT INFECTION IN CHILDREN UP TO AGE FIVE WHO HAVE THE DISEASE. ISAIAH, ISAAC AND THEIR FAMILES CONTINUE TO PARTICIPATE IN RESEARCH AND REMAIN HOPEFUL.

AUDIO
SOT/FULL Super@2:08 Isaac Okah, Jr. – Sickle Cell Patient Runs:07
“Who knows maybe they’ll come across a breakthrough and find a cure for sickle cell, I mean you never know you just gotta keep hoping for it.”

VIDEO
B-ROLL
Isaac on camera

AUDIO
VO
CATHERINE DOLF, THE JAMA REPORT.

TAG: THE EXPERT PANEL ALSO SAYS THERE ARE GAPS IN THE RESEARCH AND ALSO IN THE NUMBER OF BLOOD SPECIALISTS AND SICKLE CELL EXPERTS THAT CAN PROVIDE SPECIALIZED CARE TO PATIENTS WITH SICKLE CELL DISEASE.

INTRO: Sickle cell disease is a life-threatening genetic disorder affecting almost a hundred thousand Americans. The disease is associated with severe pain and several chronic complications. During the last five years, an expert panel reviewed existing medical studies and trials on sickle cell disease. The report highlights two therapies that are effective but underutilized when it comes to treatment. More from Catherine Dolf in this week’s JAMA Report.

VIDEO
B-ROLL
Isaiah laying in chair, pic of Isaiah in Taekwando outfit

AUDIO
VO
ISAIAH BELL IS 12. HE LOVES FOOTBALL AND TAEKWANDO.

AUDIO
SOT/FULL Super@:04 Isaiah Bell – Sickle Cell Patient Runs:04
“I get to kick people in taekwondo…that’s just awesome.”

VIDEO
B-ROLL
Pic of Isaac with diploma, with friends

AUDIO
VO
ISAAC OKAH IS 18. HE’S HEADED TO COLLEGE AND WANTS TO BE AN ACTOR.

AUDIO
SOT/FULL Super@:13 Isaac Okah, Jr. – Sickle Cell Patient Runs:04
“There are so many things about acting that just intrigues me.”

VIDEO
B-ROLL
Split screen of Isaiah sitting with mom and Isacc walking with his mom

AUDIO
VO
JUST TWO OF THE THOUSANDS LIVING WITH SICKLE CELL DISEASE IN THE UNITED STATES.

AUDIO
SOT/FULL Super@ :20 George R. Buchanan, M.D., – UT Southwestern Medical Center Runs:08
“Pain is the major manifestation of people with sickle cell disease. The pain is unpredictable, it’s recurrent and it can be extremely severe.”

VIDEO
B-ROLL
Graphic: Sickle Cells, pain points in the body

AUDIO
VO
THE PAIN IS CAUSED BY SICKLE SHAPED RED BLOODS CELLS THAT BLOCK THE SMALL BLOOD VESSELS IN THE BODY. THIS CAUSES AN ARRAY OF SERIOUS HEALTH PROBLEMS.

AUDIO
SOT/FULL Super@ :35 George R. Buchanan, M.D., – UT Southwestern Medical Center Runs:14
“Many doctors are unfamiliar with how to treat these events. Having those physicians knowledgeable about sickle cell disease and familiar with the guidelines that are being recommended here will allow them to give better care to these patients.”

(Video covering middle of bite: Dr. Buchanan talking with Isaiah and his mom)

VIDEO
B-ROLL
Dr. Buchanan walking, sitting at microscope, GXF FULL JAMA COVER

AUDIO
VO
DR. GEORGE BUCHANAN FROM THE UNIVERSITY OF TEXAS SOUTHWESTERN MEDICAL CENTER AND A PANEL OF EXPERTS SPENT 5 YEARS REVIEWING MORE THAN 30 YEARS OF MEDICAL STUDIES AND TRIALS ON SICKLE CELL DISEASE. THIS SPECIAL COMMUNICATION APPEARS IN JAMA, JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION.

AUDIO
SOT/FULL Super@ 1:04 George R. Buchanan, M.D., – UT Southwestern Medical Center Runs:13
“There are improved treatments. Hydroxyurea is greatly effective in reducing pain and other complications and prolonging patients’ lives. Unfortunately most people aren’t taking that medicine yet and it’s a big problem.”

(Video covering 2nd half of bite: cu of Dr. Buchanan’s looking in microscope

VIDEO
B-ROLL
Isaac and mom talking, blood being tested, pic of Isaac’s eyes swollen shut

AUDIO
VO
ISAAC IS TAKING THIS F-D-A APPROVED MEDICATION WHICH DECREASES THE RIGIDITY AND INFLEXIBILITY OF HIS RED BLOOD CELLS. IT IS ALSO PREVENTING EPISODES LIKE THIS.

AUDIO
SOT/FULL Super@ 1:25 Voice of: Isaac Okah, Jr. – Sickle Cell PatientRuns:03
“My eyes got swollen shut. I couldn’t see at all.”

(Video covering bite: pic of eyes swollen shut)

AUDIO
SOT/FULL Super@ 1:34 Gift Okah – Isaac’s Mother Runs:08
“For almost 5 years now we have not had any pain crisis because he stayed on that medication.”

(Video covering 1st part of bite: Isaac and mom walking)

AUDIO
SOT/FULL Super@1:41 George R. Buchanan, M.D., – UT Southwestern Medical Center Runs:10
“Blood transfusions are an extremely important treatment for people with sickle cell disease either given acutely as a single time or on a monthly basis, long-term.”

(Video covering 1st part of bite: blood transfusion bag)

AUDIO
SOT/FULL Super@1:46 Natasha Jones – Isaiah’s Mother Runs:06
“The blood transfusions just kind of helped him stay on top of his game.”

AUDIO
SOT/FULL Super@ 1:52 Isaiah Bell – Sickle Cell Patient Runs:03
“It’s not too big of a problem for me.”

VIDEO
B-ROLL
Mircroscope behind graphics:
Panel Recommendations
Treating Severe Pain with Intravenous Opiods
Using Penicillin To Treat Children Up to Age Five
Isiah and Dr. Buchanan, Isaac talking with mom

AUDIO
VO
OTHER RECOMMENDATIONS INCLUDE, TREATING SEVERE PAIN WITH INTRAVENOUS OPIODS AND USING DAILY PENICILLIN TO PREVENT INFECTION IN CHILDREN UP TO AGE FIVE WHO HAVE THE DISEASE. ISAIAH, ISAAC AND THEIR FAMILES CONTINUE TO PARTICIPATE IN RESEARCH AND REMAIN HOPEFUL.

AUDIO
SOT/FULL Super@2:08 Isaac Okah, Jr. – Sickle Cell Patient Runs:07
“Who knows maybe they’ll come across a breakthrough and find a cure for sickle cell, I mean you never know you just gotta keep hoping for it.”

VIDEO
B-ROLL
Isaac on camera

AUDIO
VO
CATHERINE DOLF, THE JAMA REPORT.

TAG: THE EXPERT PANEL ALSO SAYS THERE ARE GAPS IN THE RESEARCH AND ALSO IN THE NUMBER OF BLOOD SPECIALISTS AND SICKLE CELL EXPERTS THAT CAN PROVIDE SPECIALIZED CARE TO PATIENTS WITH SICKLE CELL DISEASE.

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